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Product Information

What is NovoLog Flexpens?

NovoLog, known as NovoRapid in Canada, contains an insulin analog made from recombinant DNA technology utilizing Saccharomyces cerevisiae to produce Insulin Aspart.

NovoLog is a sterile, aqueous, clear, and colorless solution. Each mL has 100 units of Insulin Aspart.

What is it used for?

Insulin Aspart regulates blood glucose levels in people with Diabetes mellitus. It is usually given with another type of insulin or other oral medication for diabetes in patients with Type 1 and 2 diabetes mellitus.

How does it work?

Novolog is a short-acting insulin that replaces the insulin produced by the body. It moves glucose from the blood into different body tissues. Insulin Aspart stops glucose production in the liver. Subcutaneous administration has a more rapid onset and a shorter duration of action (between 3-5 hours) than regular human insulin.

How to take it?

Never share NovoLog FlexPen with other people even if the needle is changed as it might contaminate the product and increase the risk of infection. This drug must be administered within 5 to 10 minutes before meals. Inject the drug under the skin of the stomach area, buttocks, upper legs, or upper arms. Do not use the same injection site to lessen the risk of lipodystrophy and localized cutaneous amyloidosis. Keep Novolog in the skin for 6 seconds before pulling it out. If blood appears after injection, put a little pressure in the area with a finger. Avoid rubbing or scratching the site of administration. NovoLog FlexPens are designed with Novo Nordisk 3m PenFill cartridges with NovoFine disposable needles.


NovoLog dose is individualized for each patient as total daily insulin requirement may vary and is usually between 0.5-1 units/kg/day. Any change in NovoLog dose must be cautiously made under medical supervision.

Side Effects

Some signs and symptoms of Hypoglycemia are anxiety, headache, sweating, dizziness, confusion, mood change, and irritability are seen in patients taking NovoLog. Other common side effects are low potassium in the blood, itching, injection site reactions, peripheral edema, swelling in both hands and feet, and weight gain.

Warnings, Precautions, and Contraindications

NovoLog taken with ACE inhibitors, Fluoxetine, Fibrates, Sulfonamide antibiotics, Angiotensin II blockers, MAOIs, Salicylates, and other Antidiabetic agents may result in the risk of hypoglycemia. Glucose lowering effect of NovoLog may be lessened when co-administered with Corticosteroids, Progesterones, Diuretics, Atypical antipsychotics, Thyroid hormones, Estrogens, Glucagon, and Sympathomimetic agents. Dose adjustment must be done to closely monitor blood glucose levels in patients. Sharing NovoLog devices may pose a risk for the transmission of blood-borne pathogens. Do not drive or operate heavy machinery while on this medication.

Adverse Effect

Hypoglycemia is the most common adverse effect in patients taking NovoLog. Severe low blood sugar may result in temporary or permanent brain impairment, convulsions, unconsciousness, and death. Glucose monitoring is advised for all patients taking Insulin Aspart. During animal trials, there is no direct adverse effect on the fertility of male and female rats.


A used pen can be stored at room temperature for up to 28 days while sealed NovoLog can be refrigerated up until the expiration date.


Put all used needles and cartridges in an FDA-cleared sharps disposal or a puncture-resistant container with a lid. Do not throw away needles and cartridges in the household trash. When the sharps disposal is full, follow the community guidelines in your area on how to discard sharps disposal containers.

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